The United States is home to 5 of the top 10 startup hubs in the world: Silicon Valley, New York, Boston, Los Angeles, and Seattle. Every year, a large number of unicorns are founded in the country; accounting for more than 312 of the 540 unicorns globally. It is without question that venture capital firms play a large part in making unicorns happen; they pump capital into promising startups with the value of venture capital investments amounting to roughly 333 billion US dollars.
Venture capital firms are undoubtedly a crucial source of investment for US startups, offering access to large quantities of capital, strategic assistance, industry contacts, and long-term collaborations. If you're a startup looking to grow and scale your business, then approaching a venture capital firm would be the next move for you. In this article, we have compiled a comprehensive list of venture capital firms in the United States of America so you may find the right partner for your business!
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Seed to Early Stage VCs in the United States of America
The venture capital firms listed below predominantly invest in Pre Seed to Series A startups.
Year of Inception: 2006
Stage: Pre Seed, Seed
Focus: Consumer, Crypto, Enterprise, Fintech, Healthcare, Energy, Biotechnology
Notable Portfolio: Lyft, Okta, Refinery29, Twitch, Twitter
Year of Inception: 1996
Stage: Pre Seed, Seed
Focus: Technology
Notable Portfolio: GOAT, thredUp, Ÿnsect, Clair, Rally
Year of Inception: 2004
Stage: Pre Seed, Seed, Series A
Focus: Enterprise, Consumer, Hardware, Fintech, Healthcare
Notable Portfolio: 9GAG, BirchBox, Robolox, Uber, Wikia
Year of Inception: 2017
Stage: Pre Seed, Seed, Series A
Focus: Sector Agnostic
Notable Portfolio: Base, Cabify, Mo Labs, Rocket
Year of Inception: 2010
Stage: Seed
Focus: CleanTech, High Tech, HealthTech, Apparel, Wood and Forestry Products, Food
Notable Portfolio: ESS Inc, Glider, Hubb, Opal, PrivacyCode
Year of Inception: 2009
Stage: Seed
Focus: Consumer Enterprise, Enterprise Software
Notable Portfolio: Meta, Snap, Pinterest, Dropbox, Asana, GitHub
Year of Inception: 2004
Stage: Seed
Focus: Marketplaces, Consumer, Hardware, Developer Tools & Infrastructure, B2B Applications & Services, Frontier
Notable Portfolio: ClassDojo, Eventbrite, FitBit, Poshmark, Postmates
Year of Inception: 2010
Stage: Seed
Focus: Productivity Tools, FinTech, InsurTech, SaaS, Digital Health, Future of Work
Notable Portfolio: deel, PandaDoc, OpenWeb, CarPrice, Klear
Year of Inception: 2009
Stage: Seed
Focus: Sector Agnostic
Notable Portfolio: Airtable, Uber, SeatGeek, Code Academy
Year of Inception: 1999
Stage: Seed
Focus: Sector Agnostic, Female Founders
Notable Portfolio: SoapBox, PrecisionLife, Ecotensil
Year of Inception: 2012
Stage: Seed
Focus: Technology, Software
Notable Portfolio: Crunchbase, fullcast.io, Homebase, Ironclad
Year of Inception: 1977
Stage: Seed, Series A
Focus: Applied AI, B2B SaaS, Chips & Components, Dev Tools & Infrastructure, Digital Health, Fintech, Software-Defined Hardware
Notable Portfolio: Apple, Zendesk, Hubspot
Year of Inception: 1991
Stage: Seed, Series A
Focus: Cloud, Silicon, Devices, Frontier
Notable Portfolio: Eyesmart, Qnovo, Biofurmis Inc
Year of Inception: 2008
Stage: Seed, Series A
Focus: Consumer, Enterprise, Frontier
Notable Portfolio: Airbnb, Discord, UpWork, Pendo
Year of Inception: 1987
Stage: Seed, Series A
Focus: Consumer, Fintech, Enterprise / Cloud, Frontier Tech, Digital Health, Biopharma, Medtech
Notable Portfolio: TheRealReal, Match.com, Cerexa, Zoosk
Year of Inception: 1998
Stage: Seed, Series A
Focus: Consumer Brands
Notable Portfolio: ebay, Gallant, General Assembly, Everlane, Co-Star
Year of Inception: 2008
Stage: Seed, Series A
Focus: Cyber Software, B2B Software
Notable Portfolio: Springbot, Trajektory, Matcha
Year of Inception: 2007
Stage: Seed, Series A
Focus: Enterprise, Consumer, Healthcare
Notable Portfolio: Catalytic, Vertex, Techstars
Year of Inception: 2000
Stage: Seed, Series A
Focus: Enterprise Software
Notable Portfolio: Flatfile, Honeycomb.io, CircleCi, Expel
Year of Inception: 2013
Stage: Seed, Series A
Focus: Enterprise Technology
Notable Portfolio: CopyAI, Pepperdata, Pinecone
Year of Inception: 2000
Stage: Seed, Series A
Focus: FinTech
Notable Portfolio: Payrailz, Springbot, Asset Class, Cardlytics
Year of Inception: 1985
Stage: Seed, Series A
Focus: Government, Quantum Computing, XR, Work & Human Resources, Pets, Biotechnology, Life Sciences, Food, Crypto & Digital Assets, Decentralization, Drug Discovery & Design, Education, Energy, Fintech, Healthcare, Materials, Medical Devices, Security & Identity Transportation, Mobility, Drones Legal Space, Rockets, Satellites
Notable Portfolio: AngelList, Baidu, Bitcoin, Carta, Zilingo
Year of Inception: 1996
Stage: Seed, Series A
Focus: Healthcare
Notable Portfolio: Aidin, Payground, Lumere, Kerafast, Chartwise
Year of Inception: 2000
Stage: Seed, Series A
Focus: Healthcare Technology
Notable Portfolio: Atacor Medical, Iris Healthcare, Tune Therapeutics, StrideBio
Year of Inception: 2018
Stage: Seed, Series A
Focus: Infrastructure, Software Application
Notable Portfolio: Alto, Banyan Security, Carta, Railwaye, Webflow
Year of Inception: 1985
Stage: Seed, Series A
Focus: Life Science Technology
Notable Portfolio: Snagajob, OpenSite, Alimera Sciences, CSA Medical
Year of Inception: 2014
Stage: Seed, Series A
Focus: Mobile, Consumer Internet, Enterprise, SaaS, Healthcare IT
Notable Portfolio: Astro, Exabim, Solv, TruStar Technology
Year of Inception: 2006
Stage: Seed, Series A
Focus: SaaS
Notable Portfolio: Remesh, Medpilot, Lucina, Juventas Therapeutics
Year of Inception: 2000
Stage: Seed, Series A
Focus: Science and Technology
Notable Portfolio: AllStripes, Nozomi Networks, Avail
Year of Inception: 2015
Stage: Seed, Series A
Focus: Science and Technology
Notable Portfolio: Agility Robotics, Atomic AI, Farmwise, MosaicML
Year of Inception: 2007
Stage: Seed, Series A
Focus: Sector Agnostic
Notable Portfolio: WayFinder, TrovaTrip, Sila, Notion
Year of Inception: 2007
Stage: Seed, Series A
Focus: Sector Agnostic
Notable Portfolio: Airship, Rover, Sourcepoint, AppDirect
Year of Inception: 2003
Stage: Seed, Series A
Focus: Sector Agnostic
Notable Portfolio: Doximity, Salesforce, Zoom, IrisVR
Year of Inception: 2020
Stage: Seed, Series A
Focus: Software
Notable Portfolio: Realtime, Alt, Riverside FM, QuickNode
Year of Inception: 2005
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Bloomscape, Groupon, ResoluteAI, MemberSuite
Year of Inception: 1999
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Ascent360, Tetra Insights, Resurface
Year of Inception: 1986
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: CloudFlare, BigPanda, Owlet, SteadyMD
Year of Inception: 2000
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Backbone, Graphite, Pronto, Slate
Year of Inception: 2020
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Cayena, Hippo, Kocomo, OpenStore
Year of Inception: 2017
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Wealthsimple, Instacart, SaaSLabs, Acquire, Contentful
Year of Inception: 2013
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Airbnb, BoomPop, DiDi, Laurel, Mymo
Year of Inception: 2005
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Peloton, Ring, GoodReads, SocialCast
Year of Inception: 2006
Stage: Seed, Series A
Focus: Technology
Notable Portfolio: Ribbit, Zephyr, Fresco
Year of Inception: 1970
Stage: Seed, Series A
Focus: Technology, Bio, Consumer, Enterprise
Notable Portfolio: Airtable, DoorDash, Aviatrix, Zendesk, Iterable
Year of Inception: 1977
Stage: Seed, Series A
Focus: Technology, Healthcare
Notable Portfolio: Databricks, Strive Health, Cloudflare, Instabase
Year of Inception: 2003
Stage: Seed, Series A
Focus: Web 3.0
Notable Portfolio: Twilio, DuckDuckGo, Coinbase, Etsy, Meetup, Tumblr
Year of Inception: 2005
Stage: Seed, Series A, Series B
Focus: Business Technology, Digital Experiences, Healthcare Technology
Notable Portfolio: LeanDNA, Alleviant Medical, Acessa Health, Interplay Learning
Year of Inception: 1996
Stage: Seed, Series A, Series B
Focus: Mobile, Consumer Internet, Software & Services
Notable Portfolio: Ipivot, Jaspersoft, Life360, Paycycle
Early to Late Stage VCs in the United States of America
The venture capital firms listed below predominantly invest in Series A to Series C+ startups, excluding startups at the Seed stage.
Year of Inception: 1994
Stage: Series A
Focus: Applied Technology
Notable Portfolio: Dell, Bluestone Software, Airnet, LibreDigital
Year of Inception: 2014
Stage: Series A
Focus: FinTech
Notable Portfolio: Klar, Bureau, Finkargo, Solvento
Year of Inception: 2013
Stage: Series A
Focus: Fintech, Enterprise, Marketplace, Digital Health, Logistics
Notable Portfolio: Robocorp, Zola, Northstar, Luminar
Year of Inception: 2011
Stage: Series A
Focus: Sector Agnostic
Notable Portfolio: Ario, SVT Robotics, ICX Media
Year of Inception: 2014
Stage: Series A
Focus: Software and Software-enabled Companies, Healthcare Enterprises
Notable Portfolio: BetterUp, CircleCI, Databook, Freeform
Year of Inception: 2009
Stage: Series A, Series B, Series C
Focus: American Dynamism, Bio + Health, Cultural Leadership, Consumer, Crypto Enterprise, Fintech, Games
Notable Portfolio: Boku, Asana, Slack, GitHub, Instagram
Year of Inception: 1999
Stage: Series A, Series B, Series C
Focus: Consumer, Enterprise, Application, Blockchain, Consumer, Fintech, Healthcare, Infrastructure
Notable Portfolio: Snowflake, Twilio, Guild, Railway
Founder: 1961
Year of Inception:
Stage: Series A, Series B, Series C
Focus: Consumer, Enterprise, Healthcare
Notable Portfolio: Udemy, Ritual, Calm, Excision Biotherapeutics
Year of Inception: 1911
Stage: Series A, Series B, Series C
Focus: Enterprise, Consumer, Healthcare
Notable Portfolio: Pinterest, Yelp, Toast, Wix, LinkedIn
Year of Inception: 2011
Stage: Series A, Series B, Series C
Focus: Enterprise Software, AI/ML, B2B SaaS, Crypto, Cybersecurity, Data & Analytics, DevOps, Fintech, Healthtech, Vertical SaaS
Notable Portfolio: Contentful, CloudHealth, DocuSign, Outreach
Year of Inception: 2012
Stage: Series A, Series B, Series C
Focus: Finance
Notable Portfolio: Credit Karma, Future Swap, Hippo, Robinhood
Year of Inception: 1999
Stage: Series A, Series B, Series C
Focus: Health Care, Biotechnology, Medical, Medical Device, Therapeutics
Notable Portfolio: Glaukos, Forsight Visions, Lava Therapeutics, PassageBio
Year of Inception: 2017
Stage: Series A, Series B, Series C
Focus: Life Sciences
Notable Portfolio: Kronos Bio, Quanta Therapeutics, Vigil Neuroscience
Year of Inception: 2000
Stage: Series A, Series B, Series C
Focus: Social / Internet, Enterprise Tech, Smart Tech
Notable Portfolio: Opendoor, Poshmark, Alibaba, StockX, Pinwheel
Year of Inception: 2004
Stage: Series A, Series B, Series C
Focus: Technology
Notable Portfolio: AppNexus, Atmos, Boku, Contentfly, Scribd
Year of Inception: 1969
Stage: Series A, Series B, Series C
Focus: Technology, Healthcare
Notable Portfolio: AppNexus, Zoominfo, Lyra, Dapper
Year of Inception: 2016
Stage: Series A, Series B, Series C
Focus: Life Science, BioTechnology
Notable Portfolio: Delfi, Decibel Therapeutics, SpringWorks, Genalyte
Year of Inception: 1980
Stage: Series B, Series C
Focus: Sector Agnostic
Notable Portfolio: Data.ai, Eightfold, Dropbox, Giphy
Multi-Stage VCs in the United States of America
The venture capital firms listed below invest in Pre Seed to Series C+ startups (Stage Agnostic).
Year of Inception: 2015
Stage: Pre Seed Seed Series A Series B Series C
Focus: FinTech, Healthcare, Enterprise, Opportunistic
Notable Portfolio: Evidation, Icertis, Innovaccer, Yalo
Year of Inception: 1996
Stage: Seed, Series A, Series B, Series C
Focus: AI/ML, Business Applications, Data Entertainment, FinTech, Future of Work, Healthcare, Media, Mobility, Open Source, Retail, Security, Talent
Notable Portfolio: Confluent, Figma, Revolut, Notion, Roblox
Year of Inception: 1972
Stage: Seed, Series A, Series B, Series C
Focus: AI/ML, Consumer, Cryptocurrency, Enterprise, FinTech, Healthcare
Notable Portfolio: Apple, 23andMe, Zoom, Vanta, Stripe
Year of Inception: 2013
Stage: Seed, Series A, Series B, Series C
Focus: Blockchain
Notable Portfolio: OpenSea, Kraken, AAVE
Year of Inception: 1995
Stage: Seed, Series A, Series B, Series C
Focus: Consumer, Enterprise
Notable Portfolio: Spring, Wattpad, Turo, GitLab
Year of Inception: 2000
Stage: Seed, Series A, Series B, Series C
Focus: Consumer, Enterprise, Fintech & Crypto, Health Assurance
Notable Portfolio: Stripe, Multiverse, Canva, Snap, Gusto
Year of Inception: 1976
Stage: Seed, Series A, Series B, Series C
Focus: Consumer Technology, Enterprise Technology, Healthcare Technology, SaaS, Utilitarian Consumer, FinTech, Life Sciences / Digital Health, Cybsersecurity, AI/Robotics, Infrastructure/Developer Software
Notable Portfolio: Chime, Harness, Benchling, Carta, Encoded Therapeutics
Year of Inception: 2010
Stage: Seed, Series A, Series B, Series C
Focus: Consumer Technology and Related Verticals
Notable Portfolio: Calibrate, Away, Glossier, Oura, Ritual
Year of Inception: 2010
Stage: Seed, Series A, Series B, Series C
Focus: Deep Tech
Notable Portfolio: Lumafield, OrcaBio, Starkwarve, SentinelOne, RocketLab
Year of Inception: 1994
Stage: Seed, Series A, Series B, Series C
Focus: Deep Tech, Human and Planetary Health
Notable Portfolio: FluidAI, Lingrove, STÄMM
Year of Inception: 1989
Stage: Seed, Series A, Series B, Series C
Focus: Digital Infrastructure, Enterprise Technology, Mobility
Notable Portfolio: Omnispace, Xenith, Verato, Altamira
Year of Inception: 1969
Stage: Seed, Series A, Series B, Series C
Focus: Enterprise, Consumer, Human & Planetary Health
Notable Portfolio: Outreach, Lyft, Couchbase, Quantum, SanDisk
Year of Inception: 1983
Stage: Seed, Series A, Series B, Series C
Focus: Enterprise, Broadband
Notable Portfolio: Highline, Cardlytics, Vizbee
Year of Inception: 1965
Stage: Seed, Series A, Series B, Series C
Focus: Enterprise, Consumer, Crypto
Notable Portfolio: AppDynamics, Discord, Figma, Nextdoor, Okta
Year of Inception: 1979
Stage: Seed, Series A, Series B, Series C
Focus: Enterprise IT, Internet / Digital Media, Business Services, Texas Startups
Notable Portfolio: Boomfire, CrunchFund, Black Sand Technologies
Year of Inception: 2007
Stage: Seed, Series A, Series B, Series C
Focus: FinTech
Notable Portfolio: Credit Karma, NuBank, Remitly
Year of Inception: 1984
Stage: Seed, Series A, Series B, Series C
Focus: Fintech, Apps, Infrastructure, Commerce
Notable Portfolio: Clockwise, Reprise, Airbase, Corvus, Flywire
Year of Inception: 2014
Stage: Seed, Series A, Series B, Series C
Focus: Focused Funds
Notable Portfolio: Sondermind, Hydrow, Mythical, Yumi, Willow
Year of Inception:
Stage: Seed, Series A, Series B, Series C
Focus: Healthcare
Notable Portfolio: Lumos Pharma, MannKind Corporation, Edgewise Therapeutics
Year of Inception: 2005
Stage: Seed, Series A, Series B, Series C
Focus: Healthcare
Notable Portfolio: Tiger Connect, Deciphera, Cleerly
Year of Inception: 1995
Stage: Seed, Series A, Series B, Series C
Focus: IT, BioTech
Notable Portfolio: Antithesis, Archer, DMC, Genomica
Year of Inception: 2006
Stage: Seed, Series A, Series B, Series C
Focus: Quantum & AI Health, Consumer, Web 3.0, Media & Gaming, FinTech & PropTech, Enterprise & Data, Security, Climate
Notable Portfolio: Spotify, Etsy, Circle, Grammarly
Year of Inception: 2016
Stage: Seed, Series A, Series B, Series C
Focus: Real Estate Technology
Notable Portfolio: Blend, Hippo, Opendoor, SmartRent
Year of Inception: 2006
Stage: Seed, Series A, Series B, Series C
Focus: Sector Agnostic
Notable Portfolio: Shopify, Ginkgo Bioworks, Canva, Twitcg
Year of Inception: 1997
Stage: Seed, Series A, Series B, Series C
Focus: Software, Cloud, Big Data Applications
Notable Portfolio: ZipWip, SheerID, Syndio, UpLevel
Year of Inception: 2001
Stage: Seed, Series A, Series B, Series C
Focus: TechBio (Life Science and Computer Science)
Notable Portfolio: Eko, Outpace, Rad AI, Excision Biotherapeutics
Year of Inception: 1983
Stage: Seed, Series A, Series B, Series C
Focus: Technology, Application Software, Infrastructure Software, Consumer, Industrial Tech + Life Science Tools
Notable Portfolio: Affirm, Amplitude, Groupon, Skullcandy
Year of Inception: 2000
Stage: Seed, Series A, Series B, Series C
Focus: Technology, Consumer, Enterprise
Notable Portfolio: Exabeam, Carta, Vinted, NimbleStorage
Year of Inception: 1995
Stage: Seed, Series A, Series B, Series C
Focus: Technology, Intelligent Applications, Web 3.0, Robotics, Low-Code/No-Code, Life Sciences
Notable Portfolio: Nautilus Bio, Pendulum, OctoML, Spotnana
Year of Inception: 2000
Stage: Seed, Series A, Series B, Series C
Focus: 5G, AI, Automotive, Consumer, Enterprise & Cloud, IoT, XR / Metaverse
Notable Portfolio: Cloudflare, Matterport, Sentinel One
Closing Thoughts on Venture Capitalist Firms in the United States of America
Venture capital may be a strong tool for entrepreneurs who are looking to develop and scale their operations, however, it is critical to approach the process with caution and strategy. Startups should carefully assess whether their company is at the stage to receive venture capital investments and whether the venture capital firms are a suitable fit for the company's requirements and aspirations. In the end, startups should be aware of the trade-offs that come with venture capital investments and thoughtfully plan the strategy in order to form effective collaborations with VC firms.
Find VCs and Angel Investors in major USA Cities:
Frequently Asked Questions on Venture Capitalist Firms in the United States of America
What are the top venture capital firms in the United States?
Leading American VC firms include Andreessen Horowitz, Sequoia Capital, and Accel Partners in Silicon Valley, along with notable firms like General Catalyst and Insight Partners in New York. These U.S. venture capital investors manage multi-billion dollar funds and have backed companies like Google, Facebook, and Uber. Top-tier American VCs are concentrated in major tech hubs including San Francisco Bay Area, New York, Boston, and Austin.
How much do U.S. venture capital firms typically invest?
American VC investments typically follow these ranges:
Seed Stage: $500K to $3M
Series A: $3M to $15M
Series B: $15M to $50M
Series C and beyond: $50M+
Many top U.S. venture capital firms reserve additional capital for follow-on investments in their portfolio companies, with total investment per company often exceeding $100M through multiple rounds.
What sectors do American venture capital firms focus on investing in?
U.S. venture capitalists primarily invest in high-growth sectors including:
Enterprise Software and SaaS
Artificial Intelligence/Machine Learning
Fintech and Blockchain
Healthcare Technology and Biotech
Consumer Technology
Leading American VC firms often develop specific theses around emerging technologies like quantum computing, space tech, or climate solutions, while maintaining broad technology sector coverage.
What criteria do U.S. venture capital firms use to evaluate startups?
American VCs typically assess:
Team composition and track record
Market size ($1B+ TAM minimum)
Product differentiation and IP
Traction and growth metrics
Competition and market dynamics
Unit economics and path to profitability
Exit potential (IPO or M&A prospects)
How can startups approach venture capital firms in the United States?
Entrepreneurs can connect with U.S. venture capitalists through:
Warm introductions from portfolio companies
Top-tier accelerators (Y Combinator, Techstars)
Investment bankers and startup attorneys
Demo days and pitch competitions
LinkedIn and professional networks
Most American VC firms prefer warm introductions and typically invest in companies that fit their specific investment thesis and stage focus.
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