Top 52 Angel Investor Groups in the United States of America
- Sotirios Seridis
- Feb 6
- 7 min read
For anyone looking to start a business, the United States offers nothing short of a paradise of opportunities. The country has long been renowned as the prime birthplace of innovation, evidenced by its 70% share of the North American ecosystem, which includes Silicon Valley, New York City, Boston, and Los Angeles. The startup ecosystem in the United States provides significant opportunities for entrepreneurs as well as investors. In this article, we have collected a comprehensive list of Angel Investors and Angel Investment Networks in the USA, so you may find the right partner to grow your business.
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Angel Investment Networks in the United States of America
Stage: Seed
Focus: Sector Agnostic
Year of Inception: -
Notable Portfolio: -
Location: USA-wide
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: -
Notable Portfolio: -
Location: USA-wide
Stage: Pre Seed, Seed
Focus: Sector Agnostic
Year of Inception: 2012
Notable Portfolio: Automotus, Page Vault, Rentlytics, Vapogenix
Location: Chicago
Stage: Pre Seed, Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2001
Notable Portfolio: Galen Data, SipNShut, Hoth Intelligence
Location: Texas
Stage: Pre Seed, Seed, Series A
Focus: Technology
Year of Inception: 2013
Notable Portfolio: Chattr, Clientbook, Peerfit, Stylust
Location: Florida
Stage: Seed
Focus: Information Technology, Life Science
Year of Inception: 2007
Notable Portfolio: Carmell Therapeutics, Airship, Strongwatch, Lawlytics
Location: Arizona
Stage: Seed
Focus: Sector Agnostic
Year of Inception: 2017
Notable Portfolio: MySet, Wispr Systems, Glo Cubes
Location: Alabama
Stage: Seed
Focus: Sector Agnostic, Female Founders
Year of Inception: 1999
Notable Portfolio: SoapBox, Amp.it, Repurpose, Poshly, PrecisionLife
Location: California
Stage: Seed
Focus: Technology, Internet, New Media, Healthcare and Medical Devices, Packaged Consumer Goods
Year of Inception: 2004
Notable Portfolio: Krilix, Eye-com, Unicon Systems, NX Pharmagen
Location: California
Stage: Seed
Focus: Technology, Life Science
Year of Inception: 1994
Notable Portfolio: HealthCrowd, Sherpa, Shazam, Neofroma
Location: California
Stage: Seed, Series A
Focus: B2B SaaS, Enterprise Software, FinTech, Digital Media, Medtech, Biotech, AgriFoodTech, Consumer Products
Year of Inception: 2000
Notable Portfolio: Tenacity, SuperWorld
Location: California
Stage: Seed, Series A
Focus: Consumer Products & Services, Food & Beverage, Healthcare, Industrial Internet, Mobile & Telecom, Software, FinTech, Logistics, Security
Year of Inception: 2006
Notable Portfolio: Avisa, Candidly, Loku, Pinwheel, Vertify
Location: Texas
Stage: Seed, Series A
Focus: Hard Technology
Year of Inception: 2011
Notable Portfolio: Zylo, Synode Systems, Pediatric Bioscience
Location: California
Stage: Seed, Series A
Focus: Impact
Year of Inception: 2015
Notable Portfolio: ResilientGrid, FlowBelow, Querium, Bodhi
Location: Texas
Stage: Seed, Series A
Focus: Life Science
Year of Inception: 2005
Notable Portfolio: Allylix, Carmenta, Advanced Cardiac Therapeutics, Spirox
Location: California
Stage: Seed, Series A
Focus: Life Science
Year of Inception: 2012
Notable Portfolio: PainQX, Elysium Therapeutics, Sana Health
Location: New York
Stage: Seed, Series A
Focus: Medical Diagnostics or Biopharma, Medical Devices, Non Life Science Products / Services
Year of Inception: 2016
Notable Portfolio: Arctx, Vitrivax, Lindy Biosciences, Gemelli Biotech
Location: North Carolina
Stage: Seed, Series A
Focus: Science and Technology
Year of Inception: 2000
Notable Portfolio: Circa, RevenueBase, Pixability, Netra
Location: Massachusetts
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2000
Notable Portfolio: -
Location: USA-wide chapters
Stage: Seed
Focus: Sector Agnostic
Year of Inception: 2004
Notable Portfolio: Crimson Hexagon, SeamlessDocs, Crowdly, AdStash
Location: New York
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 1997
Notable Portfolio: Abintus Bio, Beacon Healthcare, GrandPad, Green Dot, Eyedaptic
Location: California
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 1997
Notable Portfolio: Clarisonic, DocuSign, Kaskada, SoundCommerce
Location: Washington
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2003
Notable Portfolio: NuvOx Pharma, VuPulse, Admiral, Aegle Therapeutics
Location: Florida
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2008
Notable Portfolio: Lula, Consensus, RealVu, Symptom.ly
Location: Utah
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2014
Notable Portfolio: AmplifiedAg, Cure Mint, HopDrive, Zylo
Location: South Carolina
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2014
Notable Portfolio: CoreBiome, JoiaSpirit, Nomi, StemoniX
Location: Minnesota
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2015
Notable Portfolio: Brandefy, Cerillo, Karios, The Shed, Lumin
Location: Virginia
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2005
Notable Portfolio: Ideate Medical, Aptimmune, Advocado
Location: Missouri
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2003
Notable Portfolio: Abogen, Amplify, Cerahelix, Groupize
Location: Maine
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2008
Notable Portfolio: Abilitech, BrainCheck, Immerse, StreamVine, Vartega
Location: Texas
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2005
Notable Portfolio: Elevate K-12, Lumencor, Healionics
Location: Washington
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2009
Notable Portfolio: Gearbox Express, Personify, Serionix, SNOOZ
Location: Illinois
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2011
Notable Portfolio: Genomenon, Akadeum Life Sciences
Location: Michigan
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2006
Notable Portfolio: BenefitBay, Alpaca, Elevator
Location: Nebraska
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2014
Notable Portfolio: Tympanogen, Altis Biosystems, Ash & Erie
Location: Louisiana
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2012
Notable Portfolio: Bedrock Data, CampusSIMS, Mobee, Diesel Labs
Location: Massachusetts
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 1997
Notable Portfolio: Crytica Security, Membrion
Location: Nevada
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2011
Notable Portfolio: FitBark, MeetCaregivers
Location: Massachusetts
Stage: Seed, Series A
Focus: Sector Agnostic, Female Founders
Year of Inception: 2005
Notable Portfolio: Joylux, Nalu, Zenflow, Design2Launch, Amplyx
Location: New York
Stage: Seed, Series A
Focus: Sector Agnostic
Year of Inception: 2017
Notable Portfolio: VuPulse, Knack Tutoring, KinoTek, TSOLife
Location: Florida
Stage: Seed, Series A
Focus: Sector Agnostic, SaaS
Year of Inception: 2000
Notable Portfolio: Xeal, SpineAlign, Alleyoop, UNest, Basepaws
Location: California
Stage: Seed, Series A
Focus: Sector Agnostic, Trans women, cis women, nonbinary, two-spirit, agender, and gender-nonconforming founders
Year of Inception: 2011
Notable Portfolio: Invio, NeuroVice, Repurpose, Wave Therapeutics
Location: Texas
Stage: Seed, Series A
Focus: Social Impact
Year of Inception: 2015
Notable Portfolio: Connxus, Motivo, Otosense, New Wave, Livwell
Location: Colorado
Stage: Seed, Series A
Focus: Software/Healthcare, IT, Life Sciences, Hard Tech, Consumer
Year of Inception: 1999
Notable Portfolio: Quartile, WizeHive, Monetate, Synova Healthcare
Location: Pennsylvania
Stage: Seed, Series A
Focus: Sports
Year of Inception: 2017
Notable Portfolio: Oddlot, Heroclip, Alleviate, Pledge It
Location: Oregon
Stage: Seed, Series A
Focus: Technology
Year of Inception: 2000
Notable Portfolio: CloudCath, Membrion, Kiana Analytics, Orbit Fab
Location: California
Stage: Seed, Series A
Focus: Technology
Year of Inception: 2013
Notable Portfolio: Sempli, Revibe, First,io
Location: North Carolina
Stage: Seed, Series A
Focus: Technology
Year of Inception: 2003
Notable Portfolio: 4Moms, Anglr, Cognition Therapeutics, C360 Live
Location: Pennsylvania
Stage: Seed, Series A
Focus: Technology
Year of Inception: 1998
Notable Portfolio: CodeGuard, YellowCard, Clockwise.MD, Predikto
Location: Georgia
Stage: Seed, Series A
Focus: Technology
Year of Inception: 2006
Notable Portfolio: CurvaFix, Pyx Health, Vartega, Materna Medical
Location: Montana
Stage: Seed, Series A
Focus: Technology, Advanced Materials, Life Sciences, IT
Year of Inception: 2000
Notable Portfolio: Airway Therapeutics, Endosphere, Cladwell
Location: Ohio
Stage: Seed, Series A
Focus: Colorado
Notable Portfolio: Steelhead Composites, Pepper, Kick Further, Sheets & Giggles, CaliberMind
Location: Colorado
Closing Thoughts on Angel Investment Networks in the United States of America
Angel investment networks may be an excellent source of funding for American entrepreneurs. These networks can provide access to funding or individual investors, as well as mentorship and other key contacts. However, it's also important to note that it is not the only choice. Depending on the startup's specific needs and circumstances, other funding options such as venture capital, crowdsourcing, and regular bank loans may be worth pursuing.
Overall, having a clear grasp of your startup's financial requirements and goals is critical to knowing whether angel investments are a right fit for you, and having a great business strategy and a captivating pitch will help you to succeed in securing funding from the right angel investors.
Find VCs and Angel Investors in the US:
Frequently Asked Questions on Angel Investment Networks in the United States of America
What are the major angel investor networks in the United States?
The largest U.S. angel investment networks include Angel Capital Association (ACA), Tech Coast Angels, New York Angels, and Golden Seeds. These networks connect accredited investors with startups across America, with notable regional networks like Band of Angels in Silicon Valley and Hyde Park Angels in Chicago. Popular online platforms like AngelList and Gust also facilitate connections between American angels and entrepreneurs.
How much do U.S. angel investment networks typically invest in startups?
American angel networks typically invest between $25,000 to $1 million per deal, with the average angel investment being $250,000. Investment syndicates through U.S. networks often pool capital to make larger investments, sometimes reaching $2-3 million for promising startups. Most American angel groups require their members to be accredited investors, meeting SEC net worth or income requirements.
What industries do American angel investment networks focus on?
U.S. angel networks primarily invest in:
Technology and Software
Healthcare and Biotech
Consumer Products
Financial Services
Clean Energy
Many networks specialize in specific sectors, like Life Science Angels in healthcare or Clean Energy Venture Group in sustainable technologies, while others maintain diverse investment portfolios across multiple industries.
What do U.S. angel networks look for when evaluating startups?
American angel investment networks typically evaluate:
Strong founding team with proven track record
Clear market opportunity of at least $1B
Working prototype or MVP
Early customer traction or revenue
Defensible competitive advantage
Clear exit strategy within 5-7 years
Valuation typically under $10 million pre-money
How can entrepreneurs apply to U.S. angel investment networks?
Entrepreneurs can approach American angel networks through:
Direct online applications through network websites
Warm introductions from network members
Pitch competitions and demo days
Local startup accelerators
Investment platforms like AngelList Most U.S. networks have formal application processes and regular pitch meetings where selected startups present to member investors.
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